In 2003, Earth System Science Partnership (ESSP) formal decided to launch a 10-year "Monsoon Asia Integrated Regional Study" (MAIRS) proposed by Chinese scientists, and established MAIRS International Program Office (IPO) at Institute of Atmospheric Physics, Chinese Academy of Sciences in 2005. This is the first international cooperation program with importance both from national and regional in the Global Change research area that is leaded and taken the responsibility by Chinese scientists. This international program is strongly supported by Chinese Academy of Sciences, and receives a total of 15 million Chinese Yuan for its 10 years’ implementation. MAIRS is the only regional integrated research program under the framework of ESSP, and when “future Earth” launched in 2012, it has become a model for interdisciplinary research in the Asian region. Since 2006, MAIRS has made many valuable exploration integration researches in the area of water resources, land use, health, energy and other issues. MAIR has become a valuable attempt for Chinese scientists to lead the international scientific frontiers and to committee to regional cooperation and exchange. After nearly eight years of implementation, MAIRS has become an outstanding sample of regional research program. Meanwhile, as an international program promoted and led Chinese scientist, MAIRS also increases the visibility of Chinese scientists in Global Change research Area.